The information in pedigrees that is useful for mapping disease genes is sometimes limited. This…

The information in pedigrees that is useful for mapping disease genes is sometimes limited. This…
The information in pedigrees that is useful for mapping disease genes is sometimes limited. This pedigree shows segregation of neurofibromatosis, which is a fully-penetrant, autosomal dominant condition, and a single nucleotide polymorphism, SNP1, which has alleles G or T. Why is the cross in generation I not useful for determining the degree of linkage between the disease-causing gene NF and SNP1? Multiple Choice II-2 is homozygous at the SNP1 locus. I-1 is homozygous at both the disease gene and SNP loci, so the cross is not a testcross. It is impossible to determine whether II-1 has the recombinant or parental configuration of alleles, because we don't know the phase of the alleles in I-1. It is impossible to tell which SNP1 allele II-1 passed on to his children. The phase of the alleles in II-2 is unknown.     Apr 06 2022 12:54 PM

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